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    • #3
      u really need help iperson, your head is not good at all

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      • #4
        Rat poison" redirects here. For the UNIX window manager, see ratpoison. For other methods of killing rodents, see "alternatives" below.

        A roof rat in urban environmentRodenticides are a category of pest control chemicals intended to kill rodents.

        Single feed baits are chemicals sufficiently dangerous that the first dose is sufficient to kill.

        Rodents are difficult to kill with poisons because their feeding habits reflect their place as scavengers. They will eat a small bit of something and wait, and if they don't get sick, they continue. An effective rodenticide must be tasteless and odorless in lethal concentrations, and have a delayed effect.

        Contents [hide]
        1 Poisonous chemicals
        1.1 Anticoagulants
        1.2 Metal phosphides
        1.3 Hypercalcemia
        1.4 Other
        2 Alternatives
        3 List of rat eradications
        4 References
        5 External links



        [edit] Poisonous chemicals

        [edit] Anticoagulants
        Anticoagulants are defined as chronic (death occurs after 1 - 2 weeks post ingestion of the lethal dose, rarely sooner), single-dose (second generation) or multiple of the vitamin K cycle, resulting in inability to produce essential blood-clotting factors (mainly coagulation factors II (prothrombin), VII (proconvertin), IX (Christmas factor) and X (Stuart factor)).

        In addition to this specific metabolic disruption, toxic doses of 4-hydroxycoumarin or 4-hydroxythiacoumarin and indandione anticoagulants cause damage to tiny blood vessels (capillaries), increasing their permeability, causing diffuse internal bleedings (haemorrhagias). These effects are painless[citation needed] and gradual, developing over several days. In final phase of the intoxication, the exhausted rodent collapses in hypovolemic circulatory shock or severe anemia and dies calmly. Rodenticidal anticoagulants are either first generation agents (4-hydroxycoumarin type: warfarin, coumatetralyl; indandione type: pindone, diphacinone, chlorophacinone), generally requiring higher concentrations (usually between 0.005 and 0.1%) and consecutive intake over days in order to accumulate the lethal dose, and less toxic than second generation agents, which are derivatives of 4-hydroxycoumarin (difenacoum, brodifacoum, bromadiolone and flocoumafen) or difethialone (4-hydroxy-1-benzothiin-2-one, sometimes incorrectly referred to as 4-hydroxy-1-thiocoumarin, see heterocyclic compounds).

        Second generation agents are far more toxic than first generation. They are generally applied in lower concentrations in baits (usually in order 0.001 - 0.005%), are lethal after a single ingestion of bait and are also effective against strains of rodents that became resistant to first generation anticoagulants; thus, the second generation anticoagulants are sometimes referred to as "superwarfarins".

        Sometimes, anticoagulant rodenticides are potentiated by an antibiotic or bacteriostatic agent, most commonly sulfaquinoxaline. The aim of this association is that the antibiotic suppresses intestinal symbiotic microflora, which are a source of vitamin K. Diminished production of vitamin K by the intestinal microflora contributes to the action of anticoagulants. Added vitamin D also has a synergistic effect with anticoagulants.

        In some countries, fixed three-component rodenticides, i.e. anticoagulant + antibiotic + vitamin D, are used. Associations of a second-generation anticoagulant with an antibiotic and/or vitamin D are considered to be effective even against most resistant strains of rodents, though some second generation anticoagulants (namely brodifacoum and difethialone), in bait concentrations of 0.0025 - 0.005% are so toxic that resistance is unknown, and even rodents resistant to other rodenticides are reliably exterminated by application of these most toxic anticoagulants.

        Vitamin K1 has been suggested, and successfully used, as antidote for pets or humans accidentally or intentionally (poison assaults on pets, suicidal attempts) exposed to anticoagulant poisons. Some of these poisons act by inhibiting liver functions and in advanced stages of poisoning, several blood-clotting factors are absent, and the volume of circulating blood is diminished, so that a blood transfusion (optionally with the clotting factors present) can save a person who has been poisoned, an advantage over some older poisons.

        The main benefit of anticoagulants over other poisons is that the time taken for the poison to induce death means that the rats do not associate death with eating the poison.


        [edit] Metal phosphides
        Metal phosphides have been used as a means of killing rodents and are considered single-dose fast acting rodenticides (death occurs commonly within 1-3 days after single bait ingestion). A bait consisting of food and a phosphide (usually zinc phosphide) is left where the rodents can eat it. The acid in the digestive system of the rodent reacts with the phosphide to generate the toxic phosphine gas. This method of vermin control has possible use in places where rodents are resistant to some of the anticoagulants, particularly for control of house and field mice; zinc phosphide baits are also cheaper than most second-generation anticoagulants, so that sometimes, in the case of large infestation by rodents, their population is initially reduced by copious amounts of zinc phosphide bait applied, and the rest of population that survived the initial fast-acting poison is then eradicated by prolonged feeding on anticoagulant bait. Inversely, the individual rodents, that survived anticoagulant bait poisoning (rest population) can be eradicated by pre-baiting them with nontoxic bait for a week or two (this is important to overcome bait shyness, and to get rodents used to feeding in specific areas by specific food, especially in eradicating rats) and subsequently applying poisoned bait of the same sort as used for pre-baiting until all consumption of the bait ceases (usually within 2-4 days). These methods of alterning rodenticides with different modes of action gives actual or almost 100% eradications of the rodent population in the area, if the acceptance/palatability of baits are good (i.e., rodents feed on it readily).

        Zinc phosphide is typically added to rodent baits in amount of around 0.75-2%. The baits have strong, pungent garlic-like odor characteristic for phosphine liberated by hydrolysis. The odor attracts (or, at least, does not repulse) rodents, but has repulsive effect on other mammals. Birds(notably wild turkeys) are not sensitive to the smell, and will feed on the bait, and thus become collateral damage.

        The tablets or pellets (usually aluminium, calcium or magnesium phosphide for fumigation/gassing) may also contain other chemicals which evolve ammonia which helps to reduce the potential for spontaneous ignition or explosion of the phosphine gas.

        Phosphides do not accumulate in the tissues of poisoned animals, therefore the risk of secondary poisoning is low.

        Before the advent of anticoagulants, phosphides were the favored kind of rat poison. During the World War II, they came in use in United States because of shortage of strychnine due to the Japanese occupation of the territories, where strychnine-producing plants are grown (Strychnos nux-vomica, in south-east Asia). Phosphides are rather fast acting rat poisons, resulting in the rats dying usually in open areas instead of in the affected buildings.

        Phosphides used as rodenticides are:

        aluminium phosphide (fumigant only)
        calcium phosphide (fumigant only)
        magnesium phosphide (fumigant only)
        zinc phosphide (in baits)

        [edit] Hypercalcemia
        Calciferols (vitamins D), cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) are used as rodenticides. They are toxic to rodents for the same reason they are beneficial to mammals: they affect calcium and phosphate homeostasis in the body. Vitamins D are essential in minute quantities (few IUs per kilogram body weight daily, only a fraction of a miligram), and like most fat soluble vitamins, they are toxic in larger doses, causing hypervitaminosis. If the poisoning is severe enough (that is, if the dose of the toxin is high enough), it leads to death. In rodents that consume the rodenticidal bait, it causes hypercalcemia, raising the calcium level, mainly by increasing calcium absorption from food, mobilising bone-matrix-fixed calcium into ionised form (mainly monohydrogencarbonate calcium cation, partially bound to plasma proteins, [CaHCO3]+), which circulates dissolved in the blood plasma. After ingestion of a lethal dose, the free calcium levels are raised sufficiently that blood vessels, kidneys, the stomach wall and lungs are mineralised/calcificated (formation of calcificates, crystals of calcium salts/complexes in the tissues, damaging them), leading further to heart problems (myocard is sensitive to variations of free calcium levels, affecting both myocardial contractibility and excitation propagation between atrias and ventriculas), bleeding (due to capillary damage) and possibly kidney failure. It is considered to be single-dose, or cumulative (depending on concentration used; the common 0.075% bait concentration is lethal to most rodents after a single intake of larger portions of the bait), sub-chronic (death occurring usually within days to one week after ingestion of the bait). Applied concentrations are 0.075% cholecalciferol and 0.1% ergocalciferol when used alone. There is an important feature of calciferols toxicology, that they are synergistic with anticoagulant toxicants, that means, that mixtures of anticoagulants and calciferols in same bait are more toxic than a sum of toxicities of the anticoagulant and the calciferol in the bait, so that a massive hypercalcemic effect can be achieved by a substantially lower calciferol content in the bait, and vice-versa, a more pronounced anticoagulant/hemorrhagic effects are observed if the calciferol is present. This synergism is mostly used in calciferol low concetration baits, because effective concentrations of calciferols are more expensive, than effective concentrations of the most anticoagulants. The historically very first application of a calciferol in rodenticidal bait was in fact the Sorex product Sorexa® D (with a different formula than today's Sorexa® D) back in early 1970s, containing warfarin 0.025% + ergocalciferol 0.1%. Today, Sorexa® CD contains a 0.0025% difenacoum + 0.075% cholecalciferol combination. Numerous other brand products containing either calciferols 0.075 - 0.1% (f.e. Quintox®, containing 0.075% cholecalciferol) alone, or a combination of calciferol 0.01 - 0.075% with an anticoagulant are marketed.

        In family pets, accidental ingestion is generally considered safe for cats but dangerous for dogs.[1] Additional anticoagulant renders the bait more toxic to pets as well as human. Upon single ingestion, solely calciferol-based baits are considered generally safer to birds than second generation anticoagulants or acute toxicants (zinc phosphide, bromethalin, f.e.). Specific antidote for calciferol intoxication is calcitonin, a hormone, that lowers the blood levels of calcium. The therapy with commercially available calcitonin preparations is, however, expensive.

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        • #5
          pastor wright whole video

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          • #6
            Progress is coming to grips with self and acceptance of the reality of life.

            We hold these truths to be self evident



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            • #7
              She can't stop lying long enough to get a grip on reality.

              Reference

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              • #8
                <BLOCKQUOTE class="ip-ubbcode-quote"><div class="ip-ubbcode-quote-title">quote:</div><div class="ip-ubbcode-quote-content">Originally posted by ProudUSC:
                She can't stop lying long enough to get a grip on reality.

                Reference </div></BLOCKQUOTE>


                This is what happens when they have told the lie so much that it becomes a reality 4them.
                Its called MAKE THE LIE REAL syndrome.



                I guess she missed her calling.... Who knew


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                • #9
                  shes gone,shes crushed ,no she cann't.

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                  • #10
                    How can anyone be so stupid to try and lie about something that happened when she was First Lady? Duh, did she think they missed the film coverage on that one????? Unbelievable. I guess whatever 'dirty politics' it takes to try and swing voters over to her side.

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                    • #11
                      good point proud, only idiots believe this witch

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                      • #12
                        Come on iperson let's hear your response to this one..lol!
                        "Until the color of a man's skin is of no more significance than the color of his eyes everywhere will be war"...................BOB MARLEY

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                        • #13

                          Comment


                          • #14
                            <BLOCKQUOTE class="ip-ubbcode-quote"><div class="ip-ubbcode-quote-title">quote:</div><div class="ip-ubbcode-quote-content">Originally posted by ProudUSC:
                            How can anyone be so stupid to try and lie about something that happened when she was First Lady? Duh, did she think they missed the film coverage on that one????? Unbelievable. I guess whatever 'dirty politics' it takes to try and swing voters over to her side. </div></BLOCKQUOTE>


                            It is called arrogance proud. the middle name of both of the Clintons. Actually in fairness and equal opportunity, McCain is candidate too.

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                            • #15
                              <BLOCKQUOTE class="ip-ubbcode-quote"><div class="ip-ubbcode-quote-title">quote:</div><div class="ip-ubbcode-quote-content">Originally posted by iperson:
                              The problem with you guys is that you take MSM at face value. What they say is true right?

                              Well, good luck with that.

                              For the fact check on this issue visit:
                              http://facts.hillaryhub.com/archive/?id=6740 </div></BLOCKQUOTE>

                              Iperson, not having a go but you did say in another thread that the likes of CNN and other MSM were talking about that site you like to go to:

                              Quote: Dailykos is da place to be now. It's the most popular Democratic, or rather Pragmatic Progressive Blog in the whole wide world web. It's very well known, it's mentioned in the media even (CNN and others) quite frequently. Some known politicians write there as well.

                              Does that mean we shouldn't believe what CNN and other MSM say about Dailykos too then?
                              -----------------------------------------------------------------------------------------------
                              God Bless America - God Bless Immigrants - God Bless Poor Misguided Souls Too

                              National Domestic Violence Hotline:
                              1.800.799.SAFE (7233) 1.800.787.

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